Laboratoire de microbiologie, hygiène, épidémiologie hospitalisation - Hôpital de la Timone

Tél. secrétariat : 04 91 38 55 19
Fax : 04 91 38 55 18


Hôpital de la Timone


Chef de service



  • Pr Michel DRANCOURT
  • Dr Anne MOTTE
Chefs de services: 
  • Toute pathologie bactérienne
  • Tuberculose
  • Infections à mycobactéries non-tuberculeuses
Techniques et traitements
Techniques et traitements: 
  • Isolement et culture
  • Identification moléculaire
  • Identification MALDI-TOF
  • Une consultation hebdomadaire :
    - infections en neurochirurgie

Recherches :

  • Détection / identification moléculaires des bactéries
  • Identification / caractérisation des bactéries par MALDI-TOF
  • Mycobactéries émergentes
  • Borrélioses
  • Infections en ophtalmologie : kératites, uvéites


Publications :

Publications 2015:


  • Aboubaker Osman D, Bouzid F, Canaan S, Drancourt M. Smooth Tubercle Bacilli:
Neglected Opportunistic Tropical Pathogens. Front Public Health. 2016 Jan
11;3:283. doi: 10.3389/fpubh.2015.00283. eCollection 2015. Review. PubMed PMID:
26793699; PubMed Central PMCID: PMC4707939.
  • Aghnatios R, Cayrou C, Garibal M, Robert C, Azza S, Raoult D, Drancourt M.
Draft genome of Gemmata massiliana sp. nov, a water-borne Planctomycetes species
exhibiting two variants. Stand Genomic Sci. 2015 Dec 7;10:120. doi:
10.1186/s40793-015-0103-0. eCollection 2015. PubMed PMID: 26649148; PubMed
Central PMCID: PMC4672568.
  • Fotso Fotso A, Drancourt M. Laboratory Diagnosis of Tick-Borne African
Relapsing Fevers: Latest Developments. Front Public Health. 2015 Nov 11;3:254.
doi: 10.3389/fpubh.2015.00254. eCollection 2015. Review. PubMed PMID: 26618151;
PubMed Central PMCID: PMC4641162.
  • Demerle C, Ivanov V, Mercier C, Costello R, Drancourt M. Mixed Streptococcus
pneumoniae and Streptococcus pyogenes meningitis in an immunocompromised adult
patient: a case report. J Med Case Rep. 2015 Nov 29;9:273. doi:
10.1186/s13256-015-0763-9. PubMed PMID: 26615521; PubMed Central PMCID:
  • Fotso Fotso A, Mediannikov O, Nappez C, Azza S, Raoult D, Drancourt M.
Monoclonal Antibodies for the Diagnosis of Borrelia crocidurae. Am J Trop Med
Hyg. 2016 Jan 6;94(1):61-7. doi: 10.4269/ajtmh.15-0436. Epub 2015 Nov 23. PubMed
PMID: 26598566; PubMed Central PMCID: PMC4710446.
  • Asmar S, Rascovan N, Robert C, Drancourt M. Draft Genome Sequence of
Mycobacterium mucogenicum Strain CSUR P2099. Genome Announc. 2015 Nov 19;3(6).
pii: e01369-15. doi: 10.1128/genomeA.01369-15. PubMed PMID: 26586900; PubMed
Central PMCID: PMC4653802.
  • Asmar S, Drancourt M. Rapid culture-based diagnosis of pulmonary tuberculosis
in developed and developing countries. Front Microbiol. 2015 Nov 3;6:1184. doi:
10.3389/fmicb.2015.01184. eCollection 2015. Review. PubMed PMID: 26579092; PubMed
Central PMCID: PMC4630581.
  • Asmar S, Robert C, Croce O, Caputo A, Drancourt M. Draft Genome Sequence of
Mycobacterium neworleansense Strain ATCC 49404T. Genome Announc. 2015 Nov 5;3(6).
pii: e01314-15. doi: 10.1128/genomeA.01314-15. PubMed PMID: 26543131; PubMed
Central PMCID: PMC4645216.
  • Asmar S, Rascovan N, Robert C, Drancourt M. Draft Genome Sequence of
Mycobacterium peregrinum Strain CSUR P2098. Genome Announc. 2015 Nov 5;3(6). pii:
e01274-15. doi: 10.1128/genomeA.01274-15. PubMed PMID: 26543113; PubMed Central
PMCID: PMC4645198.
  • Tian RD, Lepidi H, Nappez C, Drancourt M. Experimental Survival of
Mycobacterium ulcerans in Watery Soil, a Potential Source of Buruli Ulcer. Am J
Trop Med Hyg. 2016 Jan 6;94(1):89-92. doi: 10.4269/ajtmh.15-0568. Epub 2015 Nov
2. PubMed PMID: 26526927; PubMed Central PMCID: PMC4710452.
  • Edouard S, Courtois GD, Gautret P, Jouve JL, Minodier P, Noël G, Roch A,
Brouqui P, Stein A, Drancourt M, Fournier PE, Raoult D. High Prevalence of
Mycoplasma faucium DNA in the Human Oropharynx. J Clin Microbiol. 2016
Jan;54(1):194-6. doi: 10.1128/JCM.02068-15. Epub 2015 Oct 28. PubMed PMID:
26511735; PubMed Central PMCID: PMC4702739.
  • Phelippeau M, Dubus JC, Reynaud-Gaubert M, Gomez C, Stremler le Bel N,
Bedotto M, Prudent E, Drancourt M. Prevalence of Mycobacterium lentiflavum in
cystic fibrosis patients, France. BMC Pulm Med. 2015 Oct 26;15:131. doi:
10.1186/s12890-015-0123-y. PubMed PMID: 26503635; PubMed Central PMCID:
  • Fotso Fotso A, Angelakis E, Mouffok N, Drancourt M, Raoult D. Blood-Borne
Candidatus Borrelia algerica in a Patient with Prolonged Fever in Oran, Algeria.
Am J Trop Med Hyg. 2015 Nov;93(5):1070-3. doi: 10.4269/ajtmh.15-0124. Epub 2015
Sep 28. PubMed PMID: 26416117; PubMed Central PMCID: PMC4703269.
  • Dubourg G, Delord M, Gouriet F, Fournier PE, Drancourt M. Actinomyces
gerencseriae hip prosthesis infection: a case report. J Med Case Rep. 2015 Sep
28;9:223. doi: 10.1186/s13256-015-0704-7. PubMed PMID: 26415492; PubMed Central
PMCID: PMC4587881.
  • Phelippeau M, Djaltou AO, Musso D, Drancourt M. Epidemiology of
nontuberculous mycobacteria in French Polynesia. J Clin Microbiol. 2015 Sep 23.
pii: JCM.01560-15. [Epub ahead of print] PubMed PMID: 26400787; PubMed Central
PMCID: PMC4652114.
  • Fournier PE, Drancourt M, Aboudharam G, Raoult D. Paleomicrobiology of
Bartonella infections. Microbes Infect. 2015 Nov-Dec;17(11-12):879-83. doi:
10.1016/j.micinf.2015.09.002. Epub 2015 Sep 11. PubMed PMID: 26369716.
  • Osman DA, Phelippeau M, Drancourt M, Musso D. Diversity of Mycobacterium
tuberculosis lineages in French Polynesia. J Microbiol Immunol Infect. 2015 Jun
30. pii: S1684-1182(15)00774-4. doi: 10.1016/j.jmii.2015.05.018. [Epub ahead of
print] PubMed PMID: 26271142.
  • Asmar S, Phelippeau M, Robert C, Croce O, Drancourt M. Draft Genome Sequence
of Mycobacterium bohemicum Strain DSM 44277T. Genome Announc. 2015 Aug 6;3(4).
pii: e00878-15. doi: 10.1128/genomeA.00878-15. PubMed PMID: 26251499; PubMed
Central PMCID: PMC4541277.
  • Asmar S, Drancourt M. Chlorhexidine decontamination of sputum for culturing
Mycobacterium tuberculosis. BMC Microbiol. 2015 Aug 5;15:155. doi:
10.1186/s12866-015-0479-4. PubMed PMID: 26238865; PubMed Central PMCID:
  • Phelippeau M, Croce O, Robert C, Raoult D, Drancourt M. Draft Genome Sequence
of Mycobacterium lentiflavum CSUR P1491. Genome Announc. 2015 Jul 23;3(4). pii:
e00817-15. doi: 10.1128/genomeA.00817-15. PubMed PMID: 26205866; PubMed Central
PMCID: PMC4513160.
  • Phelippeau M, Croce O, Robert C, Raoult D, Drancourt M. Draft Genome Sequence
of Mycobacterium europaeum Strain CSUR P1344. Genome Announc. 2015 Jul 23;3(4).
pii: e00816-15. doi: 10.1128/genomeA.00816-15. PubMed PMID: 26205865; PubMed
Central PMCID: PMC4513159.
  • Fournier PE, Drancourt M. New Microbes New Infections promotes modern
prokaryotic taxonomy: a new section "TaxonoGenomics: new genomes of
microorganisms in humans". New Microbes New Infect. 2015 Jun 9;7:48-9. doi:
10.1016/j.nmni.2015.06.001. eCollection 2015 Sep. PubMed PMID: 26199732; PubMed
Central PMCID: PMC4506979.
  • Huynh HT, Verneau J, Levasseur A, Drancourt M, Aboudharam G. Bacteria and
archaea paleomicrobiology of the dental calculus: a review. Mol Oral Microbiol.
2015 Jul 21. doi: 10.1111/omi.12118. [Epub ahead of print] Review. PubMed PMID:
  • Huynh HT, Gotthard G, Terras J, Aboudharam G, Drancourt M, Chabrière E.
Surface plasmon resonance imaging of pathogens: the Yersinia pestis paradigm. BMC
Res Notes. 2015 Jun 24;8:259. doi: 10.1186/s13104-015-1236-3. PubMed PMID:
26105071; PubMed Central PMCID: PMC4479326.
  • Ghodbane R, Asmar S, Betzner M, Linet M, Pierquin J, Raoult D, Drancourt M.
Rapid Diagnosis of Tuberculosis by Real-Time High-Resolution Imaging of
Mycobacterium tuberculosis Colonies. J Clin Microbiol. 2015 Aug;53(8):2693-6.
doi: 10.1128/JCM.00684-15. Epub 2015 Jun 17. PubMed PMID: 26085608; PubMed
Central PMCID: PMC4508418.
  • Aghnatios R, Drancourt M. Colonization of Hospital Water Networks by Gemmata
massiliana, a New Planctomycetes Bacterium. Curr Microbiol. 2015
Sep;71(3):317-20. doi: 10.1007/s00284-015-0845-3. Epub 2015 Jun 7. PubMed PMID:
  • Aboubaker Osman D, Phelippeau M, Musso D, Robert C, Michelle C, Croce O,
Drancourt M. Draft Genome Sequence of Mycobacterium tuberculosis Strain MT43, a
Representative of the Manu2 Genotype. Genome Announc. 2015 Jun 4;3(3). pii:
e00579-15. doi: 10.1128/genomeA.00579-15. PubMed PMID: 26044427; PubMed Central
PMCID: PMC4457064.
  • Aboubaker Osman D, Phelippeau M, Musso D, Robert C, Michelle C, Croce O,
Drancourt M. Draft Genome Sequence of Mycobacterium tuberculosis Strain MT11,
Which Represents a New Lineage. Genome Announc. 2015 Jun 4;3(3). pii: e00573-15.
doi: 10.1128/genomeA.00573-15. PubMed PMID: 26044426; PubMed Central PMCID:
  • Asmar S, Chatellier S, Mirande C, van Belkum A, Canard I, Raoult D, Drancourt
M. A Novel Solid Medium for Culturing Mycobacterium tuberculosis Isolates from
Clinical Specimens. J Clin Microbiol. 2015 Aug;53(8):2566-9. doi:
10.1128/JCM.01149-15. Epub 2015 Jun 3. PubMed PMID: 26041897; PubMed Central
PMCID: PMC4508397.
  • Mougin B, Tian RB, Drancourt M. Tropical Plant Extracts Modulating the Growth
of Mycobacterium ulcerans. PLoS One. 2015 Apr 23;10(4):e0124626. doi:
10.1371/journal.pone.0124626. eCollection 2015. PubMed PMID: 25905816; PubMed
Central PMCID: PMC4408112.
  • Yin N, Delord M, Giovanni A, del Grande J, Drancourt M, Brouqui P, Lagier JC.
Laryngeal tuberculosis diagnosed by stool sample cultures: a case report. J Med
Case Rep. 2015 Mar 31;9:74. doi: 10.1186/s13256-015-0548-1. PubMed PMID:
25886183; PubMed Central PMCID: PMC4381499.
  • Fournier A, Gouriet F, Fournier PE, Casalta JP, Saby L, Habib G, Drancourt M,
Raoult D. A case of infectious endocarditis due to BCG. Int J Infect Dis. 2015
Jun;35:27-8. doi: 10.1016/j.ijid.2015.04.003. Epub 2015 Apr 11. PubMed PMID:
  • Huynh HT, Pignoly M, Nkamga VD, Drancourt M, Aboudharam G. The repertoire of
archaea cultivated from severe periodontitis. PLoS One. 2015 Apr
1;10(4):e0121565. doi: 10.1371/journal.pone.0121565. eCollection 2015. PubMed
PMID: 25830311; PubMed Central PMCID: PMC4382158.
  • Carrère-Kremer S, Blaise M, Singh VK, Alibaud L, Tuaillon E, Halloum I, van
de Weerd R, Guérardel Y, Drancourt M, Takiff H, Geurtsen J, Kremer L. A new
dehydratase conferring innate resistance to thiacetazone and intra-amoebal
survival of Mycobacterium smegmatis. Mol Microbiol. 2015 Jun;96(5):1085-102. doi:
10.1111/mmi.12992. Epub 2015 Mar 28. PubMed PMID: 25754266.
  • Phelippeau M, Musso D, Drancourt M. Mycobacterium abscessus pneumonia in a
South Pacific islander. J Microbiol Immunol Infect. 2015 Jan 30. pii:
S1684-1182(15)00032-8. doi: 10.1016/j.jmii.2015.01.008. [Epub ahead of print]
PubMed PMID: 25731702.
  • Nkamga VD, Huynh HT, Aboudharam G, Ruimy R, Drancourt M. Diversity of
human-associated Methanobrevibacter smithii isolates revealed by multispacer
sequence typing. Curr Microbiol. 2015 Jun;70(6):810-5. doi:
10.1007/s00284-015-0787-9. Epub 2015 Feb 24. PubMed PMID: 25708582.
  • Gouba N, Drancourt M. Digestive tract mycobiota: a source of infection. Med
Mal Infect. 2015 Jan-Feb;45(1-2):9-16. doi: 10.1016/j.medmal.2015.01.007. Epub
2015 Feb 13. Review. PubMed PMID: 25684583.
  • Huynh HT, Nkamga VD, Drancourt M, Aboudharam G. Genetic variants of dental
plaque Methanobrevibacter oralis. Eur J Clin Microbiol Infect Dis. 2015
Jun;34(6):1097-101. doi: 10.1007/s10096-015-2325-x. Epub 2015 Jan 30. PubMed
PMID: 25633825.
  • Lagier JC, Edouard S, Pagnier I, Mediannikov O, Drancourt M, Raoult D.
Current and past strategies for bacterial culture in clinical microbiology. Clin
Microbiol Rev. 2015 Jan;28(1):208-36. doi: 10.1128/CMR.00110-14. Review. PubMed
PMID: 25567228; PubMed Central PMCID: PMC4284306.
  • Morel AS, Dubourg G, Prudent E, Edouard S, Gouriet F, Casalta JP, Fenollar F,
Fournier PE, Drancourt M, Raoult D. Complementarity between targeted real-time
specific PCR and conventional broad-range 16S rDNA PCR in the syndrome-driven
diagnosis of infectious diseases. Eur J Clin Microbiol Infect Dis. 2015
Mar;34(3):561-70. doi: 10.1007/s10096-014-2263-z. Epub 2014 Oct 28. PubMed PMID:
  • Mgode GF, Cohen-Bacrie S, Bedotto M, Weetjens BJ, Cox C, Jubitana M, Kuipers
D, Machang'u RS, Kazwala R, Mfinanga SG, Kaufmann SH, Drancourt M. Mycobacterium
genotypes in pulmonary tuberculosis infections and their detection by trained
African giant pouched rats. Curr Microbiol. 2015 Feb;70(2):212-8. doi:
10.1007/s00284-014-0705-6. Epub 2014 Oct 2. PubMed PMID: 25274413.


  • Seng P, Rolain JM, Fournier PE, La Scola B, Drancourt M, Raoult D. MALDI-TOF-mass spectrometry applications in clinical microbiology. Future Microbiol. 2010 Nov;5:1733-54.
  • Ayyadurai S, Flaudrops C, Raoult D, Drancourt M. Rapid identification and typing of Yersinia pestis and other Yersinia species by matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry. BMC Microbiol. 2010 Nov 12;10:285.
  • Nguyen-Hieu T, Aboudharam G, Signoli M, Rigeade C, Drancourt M, Raoult D. Evidence of a louse-borne outbreak involving typhus in Douai, 1710-1712 during the war of Spanish succession. PLoS One. 2010 Oct 27;5(10):e15405.
  • Ninove L, Nougairede A, Gazin C, Zandotti C, Drancourt M, de Lamballerie X, Charrel RN. POC tests: from antigen detection to molecular methods. Future trends. J Clin Virol. 2010 Dec;49(4):304-5.
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