HARLÉ Jean-Robert

Recherches :

• Cryoglobuline
• Maladie coeliaque
• Syndrome des antiphospholipides (notamment étude des rapports avec l'hypergammaglobulinémie M)
• Déficit en IgA
• Maladie périodique
• Syndrome hypereosinophilique
• État d'hypergastrinémie
• Artérite du Cannabis
• Syndrome des lymphocytes bi-nuclées
• Mastocytoses systémiques
• Maladie de Erdheim-Chester
• Sclérodermie
• Maladies auto-inflammatoires
• Amylose à lysozyme
• Myopathies inflammatoires
• Cytopathies mitochondriales
• Thrombocytémie essentielle

Principales publications récentes indexées dans la base de données Pubmed 2301-2014

• Grados A, Ebbo M, Jean E, Bernit E, Harlé JR, Schleinitz N. [IgG4-related disease treatment in 2014: Update and literature review.]. Rev Med Interne. 2015 Jan 13.

• London J, Grados A, Fermé C, Charmillon A, Maurier F, Deau B, Crickx E, Brice P, Chapelon-Abric C, Haioun C, Burroni B, Alifano M, Le Jeunne C, Guillevin L,Costedoat-Chalumeau N, Schleinitz N, Mouthon L, Terrier B. Sarcoidosis occurring after lymphoma: report of 14 patients and review of the literature. Medicine (Baltimore). 2014 Nov;93(21

• Lefèvre G, Meyer A, Launay D, Machelart I, DeBandt M, Michaud J, Tournadre A, Godmer P, Kahn JE, Behra-Marsac A, Timsit MA, Schleinitz N, Wendling D, Melac-Ducamp S, Boyer P, Peretz A, Lequerré T, Richez C, Stervinou-Wemeau L, Morell-Dubois S, Lambert M, Dubucquoi S, Wallaert B, Benveniste O, Flipo RM, Hatron PY, Sibilia J, Hachulla E, Hervier B; on behalf of the Club Rhumatismes, Inflammation. Seronegative polyarthritis revealing antisynthetase syndrome: a multicentre study of 40 patients. Rheumatology (Oxford). 2014 Oct 27.

• Jean E, Ebbo M, Valleix S, Benarous L, Heyries L, Grados A, Bernit E, Grateau G, Papo T, Granel B, Daniel L, Harlé JR, Schleinitz N. A new family with hereditary lysozyme amyloidosis with gastritis and inflammatory bowel disease as prevailing symptoms. BMC Gastroenterol. 2014 Sep 13;14:159.

• Seguier J, Guillaume-Jugnot P, Ebbo M, Daniel L, Jourde-Chiche N, Burtey S, Bernit E, Thomas P, Harlé JR, Schleinitz N. [Thymic disease associated with nephrotic syndrome: A new case with membranous nephropathy and literature review.]. Rev Med Interne. 2014 Aug 26.

• Saison J, Costedoat-Chalumeau N, Maucort-Boulch D, Iwaz J, Marignier R, Cacoub P, Vital-Durand D, Hot A, Tebib J, Aumaitre O, Schleinitz N, Sarrot-Reynauld F, Broussolle C, Sève P. Systemic lupus erythematosus-associated acute transverse myelitis: manifestations, treatments, outcomes, and prognostic factors in 20 patients. Lupus. 2015 Jan;24(1):74-81

• Colavolpe C, Ebbo M, Trousse D, Khibri H, Franques J, Chetaille B, Coso D, Ouvrier MJ, Gastaud L, Guedj E, Schleinitz N. FDG-PET/CT is a pivotal imaging modality to diagnose rare intravascular large B-cell lymphoma: case report and review of literature. Hematol Oncol. 2014 May 21.

• Mahévas M, Fain O, Ebbo M, Roudot-Thoraval F, Limal N, Khellaf M, Schleinitz N, Bierling P, Languille L, Godeau B, Michel M. The temporary use of thrombopoietin-receptor agonists may induce a prolonged remission in adult chronic immune thrombocytopenia. Results of a French observational study. Br J Haematol. 2014 Jun;165(6):865-9.

• Audemard A, Lamy T, Bareau B, Sicre F, Suarez F, Truquet F, Salaun V, Macro M, Verneuil L, Lobbedez T, Castrale C, Boutemy J, Cheze S, Geffray L, Schleinitz N, Rey J, Lazaro E, Guillevin L, Bienvenu B. Vasculitis associated with large granular lymphocyte (LGL) leukemia: presentation and treatment outcomes of 11 cases. Semin Arthritis Rheum. 2013 Dec;43(3):362-6.

• Gouilleux-Gruart V, Schleinitz N, Fischer A. Primary immune deficiencies: practical questions. Curr Opin Allergy Clin Immunol. 2013 Jul;13 Suppl 2:S67-78.

• Ebbo M, Grados A, Guedj E, Gobert D, Colavolpe C, Zaidan M, Masseau A, Bernard F, Berthelot JM, Morel N, Lifermann F, Palat S, Haroche J, Mariette X, Godeau B, Bernit E, Costedoat-Chalumeau N, Papo T, Hamidou M, Harlé JR, Schleinitz N. Usefulness of 2-[18F]-fluoro-2-deoxy-D-glucose-positron emission tomography/computed tomography for staging and evaluation of treatment response in IgG4-related disease: a retrospective multicenter study. Arthritis Care Res (Hoboken). 2014 Jan;66(1):86-96.

• Mahévas M, Ebbo M, Audia S, Bonnotte B, Schleinitz N, Durand JM, Chiche L, Khellaf M, Bierling P, Roudot-Thoraval F, Godeau B, Michel M. Efficacy and safety of rituximab given at 1,000 mg on days 1 and 15 compared to the standard regimen to treat adult immune thrombocytopenia. Am J Hematol. 2013 Oct;88(10):858-61.

• Ebbo M, Grados A, Schleinitz N. [IgG4-related disease]. Rev Prat. 2013 May;63(5):605-10

• Mosnier E, Charrel R, Vidal B, Ninove L, Schleinitz N, Harlé JR, Bernit E. Toscana virus myositis and fasciitis. Med Mal Infect. 2013 May;43(5):208-10. doi:

• Ebbo M, Chagnaud C, Figarella-Branger D, Legall S, Harle JR, Schleinitz N. Antisynthethase syndrome presenting as peripheral limb fasciitis. Joint Bone Spine. 2013 Oct;80(5):528-30. doi:

• Poisnel E, Ebbo M, Berda-Haddad Y, Faucher B, Bernit E, Carcy B, Piarroux R,  Harlé JR, Schleinitz N. Babesia microti: an unusual travel-related disease. BMC Infect Dis. 2013 Feb 22;13:99

• Fernandez C, Bardin N, De Paula AM, Salort-Campana E, Benyamine A, Franques J, Schleinitz N, Weiller PJ, Pouget J, Pellissier JF, Figarella-Branger D. Correlation of clinicoserologic and pathologic classifications of inflammatory myopathies: study of 178 cases and guidelines for diagnosis. Medicine (Baltimore). 2013 Jan;92(1):15-24.

• Hart PA, Kamisawa T, Brugge WR, Chung JB, Culver EL, Czakó L, Frulloni L, Go VL, Gress TM, Kim MH, Kawa S, Lee KT, Lerch MM, Liao WC, Löhr M, Okazaki K, Ryu JK, Schleinitz N, Shimizu K, Shimosegawa T, Soetikno R, Webster G, Yadav D, Zen Y, Chari ST. Long-term outcomes of autoimmune pancreatitis: a multicentre, international analysis. Gut. 2013 Dec;62(12):1771-6. doi:

• Boursiquot JN, Gérard L, Malphettes M, Fieschi C, Galicier L, Boutboul D, Borie R, Viallard JF, Soulas-Sprauel P, Berezne A, Jaccard A, Hachulla E, Haroche J, Schleinitz N, Têtu L, Oksenhendler E; DEFI study group. Granulomatous disease in CVID: retrospective analysis of clinical characteristics and treatment efficacy in a cohort of 59 patients. J Clin Immunol. 2013 Jan;33(1):84-95.

• Lambotte O, Neven B, Galicier L, Magerus-Chatinet A, Schleinitz N, Hermine O, Meyts I, Picard C, Godeau B, Fischer A, Rieux-Laucat F. Diagnosis of autoimmune lymphoproliferative syndrome caused by FAS deficiency in adults. Haematologica. 2013 Mar;98(3):389-92.