Recherches :
Le Service de Neurophysiologie Clinique de l’APHM est associé à l’INSERM et à l’Université d’Aix-Marseille dans l’Unité Mixte de Recherche « Institut de Neurosciences des Systèmes, INS» (INSERM UMR 1106, Dir. Viktor Jirsa). L’équipe « Épilepsie » travaille sur la physiopathologie des épilepsies, et recherche de nouvelles formes de traitement à la fois sur le plan expérimental et sur les données humaines. (site internet : (
http://ins.univ-amu.fr/).
L’équipe clinique est intégrée à la Fédération Hospitalo-Universitaire "EPINEXT" (« Epilepsies and disorders of Neuronal Excitability ») (Directeur : Pr F Bartolomei) labélisée récemment par l'Université Aix Marseille et dédiée à la recherche et la prise en charge des épilepsies. Il s'agit du plus important regroupement d'équipes de recherche (11 unités INSERM y sont associées) sur l'épilepsie. Pour plus d'infos: http://www.epinext.org/
Publications : Exemples de publications récentes du service en Epileptologie
Bartolomei F, Trébuchon A, Bonini F, Lambert I, Gavaret M, Woodman M, Giusiano
B, Wendling F, Bénar C. What is the concordance between the seizure onset zone
and the irritative zone? A SEEG quantified study. Clin Neurophysiol. 2015 Oct 19.
pii: S1388-2457(15)00982-7. doi: 10.1016/j.clinph.2015.10.029. [Epub ahead of
print] PubMed PMID: 26520456.
Guerrini R, Duchowny M, Jayakar P, Krsek P, Kahane P, Tassi L, Melani F,
Polster T, Andre VM, Cepeda C, Krueger DA, Cross JH, Spreafico R, Cosottini M,
Gotman J, Chassoux F, Ryvlin P, Bartolomei F, Bernasconi A, Stefan H, Miller I,
Devaux B, Najm I, Giordano F, Vonck K, Barba C, Blumcke I. Diagnostic methods and
treatment options for focal cortical dysplasia. Epilepsia. 2015
Nov;56(11):1669-86. doi: 10.1111/epi.13200. Epub 2015 Oct 5. Review. PubMed PMID:
26434565.
Evangelista E, Bénar C, Bonini F, Carron R, Colombet B, Régis J, Bartolomei F.
Does the Thalamo-Cortical Synchrony Play a Role in Seizure Termination? Front
Neurol. 2015 Sep 1;6:192. doi: 10.3389/fneur.2015.00192. eCollection 2015. PubMed
PMID: 26388834; PubMed Central PMCID: PMC4555023.
Alexandre V, Mercedes B, Valton L, Maillard L, Bartolomei F, Szurhaj W, Hirsch
E, Marchal C, Chassoux F, Petit J, Crespel A, Nica A, Navarro V, Kahane P, De
Toffol B, Thomas P, Rosenberg S, Denuelle M, Jonas J, Ryvlin P, Rheims S;
REPO2MSE study group. Risk factors of postictal generalized EEG suppression in
generalized convulsive seizures. Neurology. 2015 Nov 3;85(18):1598-603. doi:
10.1212/WNL.0000000000001949. Epub 2015 Sep 2. PubMed PMID: 26333799.
Garbelli R, de Bock F, Medici V, Rousset MC, Villani F, Boussadia B,
Arango-Lievano M, Jeanneteau F, Daneman R, Bartolomei F, Marchi N. PDGFRβ(+)
cells in human and experimental neuro-vascular dysplasia and seizures.
Neuroscience. 2015 Oct 15;306:18-27. doi: 10.1016/j.neuroscience.2015.07.090.
Epub 2015 Aug 15. PubMed PMID: 26283024.
Muldoon SF, Villette V, Tressard T, Malvache A, Reichinnek S, Bartolomei F,
Cossart R. GABAergic inhibition shapes interictal dynamics in awake epileptic
mice. Brain. 2015 Oct;138(Pt 10):2875-90. doi: 10.1093/brain/awv227. Epub 2015
Aug 13. PubMed PMID: 26280596.
Badier JM, Bénar CG, Woodman M, Cruto C, Chauvel P, Bartolomei F, Gavaret M.
Ictal Magnetic Source Imaging in Presurgical Assessment. Brain Topogr. 2015 Aug
12. [Epub ahead of print] PubMed PMID: 26264375.
Bodin C, Aubert S, Daquin G, Carron R, Scavarda D, McGonigal A, Bartolomei F.
Responders to vagus nerve stimulation (VNS) in refractory epilepsy have reduced
interictal cortical synchronicity on scalp EEG. Epilepsy Res. 2015
Jul;113:98-103. doi: 10.1016/j.eplepsyres.2015.03.018. Epub 2015 Apr 9. PubMed
PMID: 25986196.
Bonini F, Lambert I, Wendling F, McGonigal A, Bartolomei F. Altered synchrony
and loss of consciousness during frontal lobe seizures. Clin Neurophysiol. 2015
Apr 15. pii: S1388-2457(15)00286-2. doi: 10.1016/j.clinph.2015.04.050. [Epub
ahead of print] PubMed PMID: 25912335.
Becker C, Bouvier E, Ghestem A, Siyoucef S, Claverie D, Camus F, Bartolomei
F, Benoliel JJ, Bernard C. Predicting and treating stress-induced vulnerability
to epilepsy and depression. Ann Neurol. 2015 Jul;78(1):128-36. doi:
10.1002/ana.24414. Epub 2015 May 25. PubMed PMID: 25869354.
Wendling F, Benquet P, Bartolomei F, Jirsa V. Computational models of
epileptiform activity. J Neurosci Methods. 2015 Apr 3. pii:
S0165-0270(15)00122-3. doi: 10.1016/j.jneumeth.2015.03.027. [Epub ahead of print]
Review. PubMed PMID: 25843066.
Guedj E, Bonini F, Gavaret M, Trébuchon A, Aubert S, Boucekine M, Boyer L,
Carron R, McGonigal A, Bartolomei F. 18FDG-PET in different subtypes of temporal
lobe epilepsy: SEEG validation and predictive value. Epilepsia. 2015
Mar;56(3):414-21. doi: 10.1111/epi.12917. Epub 2015 Feb 23. PubMed PMID:
25708545.
Jehi L, Yardi R, Chagin K, Tassi L, Russo GL, Worrell G, Hu W, Cendes F,
Morita M, Bartolomei F, Chauvel P, Najm I, Gonzalez-Martinez J, Bingaman W,
Kattan MW. Development and validation of nomograms to provide individualised
predictions of seizure outcomes after epilepsy surgery: a retrospective analysis.
Lancet Neurol. 2015 Mar;14(3):283-90. doi: 10.1016/S1474-4422(14)70325-4. Epub
2015 Jan 29. PubMed PMID: 25638640.
Micoulaud-Franchi JA, Barkate G, Trébuchon-Da Fonseca A, Vaugier L, Gavaret
M, Bartolomei F, McGonigal A. One step closer to a global tool for rapid
screening of major depression in epilepsy: validation of the French NDDI-E.
Epilepsy Behav. 2015 Mar;44:11-6. doi: 10.1016/j.yebeh.2014.12.011. Epub 2015 Jan
16. PubMed PMID: 25597527.
Arthuis M, Micoulaud-Franchi JA, Bartolomei F, McGonigal A, Guedj E. Resting
cortical PET metabolic changes in psychogenic non-epileptic seizures (PNES). J
Neurol Neurosurg Psychiatry. 2015 Oct;86(10):1106-12. doi:
10.1136/jnnp-2014-309390. Epub 2014 Dec 2. PubMed PMID: 25466258.
Micoulaud-Franchi JA, Kotwas I, Lanteaume L, Berthet C, Bastien M, Vion-Dury
J, McGonigal A, Bartolomei F. Skin conductance biofeedback training in adults
with drug-resistant temporal lobe epilepsy and stress-triggered seizures: a
proof-of-concept study. Epilepsy Behav. 2014 Dec;41:244-50. doi:
10.1016/j.yebeh.2014.10.017. Epub 2014 Nov 5. PubMed PMID: 25461224.
Proix T, Bartolomei F, Chauvel P, Bernard C, Jirsa VK. Permittivity coupling
across brain regions determines seizure recruitment in partial epilepsy. J
Neurosci. 2014 Nov 5;34(45):15009-21. doi: 10.1523/JNEUROSCI.1570-14.2014. PubMed
PMID: 25378166.
McGonigal A, Bartolomei F, Gavaret M, Chauvel P, Régis J. Gamma knife
radiosurgery of paracentral epilepsy. Stereotact Funct Neurosurg.
2014;92(6):346-53. doi: 10.1159/000364915. Epub 2014 Oct 28. PubMed PMID:
25358847.
Badier JM, Bartolomei F, Chauvel P, Bénar CG, Gavaret M. Magnetic source
imaging in posterior cortex epilepsies. Brain Topogr. 2015 Jan;28(1):162-71. doi:
10.1007/s10548-014-0412-4. Epub 2014 Oct 29. PubMed PMID: 25352165.
de la Vaissière S, Milh M, Scavarda D, Carron R, Lépine A, Trébuchon A,
Gavaret M, Hewett R, Laguitton V, Daquin G, Villeneuve N, Bartolomei F. Cortical
involvement in focal epilepsies with epileptic spasms. Epilepsy Res. 2014
Nov;108(9):1572-80. doi: 10.1016/j.eplepsyres.2014.08.008. Epub 2014 Aug 30.
PubMed PMID: 25212728.
Koubeissi MZ, Bartolomei F, Beltagy A, Picard F. Electrical stimulation of a
small brain area reversibly disrupts consciousness. Epilepsy Behav. 2014
Aug;37:32-5. doi: 10.1016/j.yebeh.2014.05.027. Epub 2014 Jun 24. PubMed PMID:
24967698.
Sevy A, Gavaret M, Trebuchon A, Vaugier L, Wendling F, Carron R, Regis J,
Chauvel P, Gonigal AM, Bartolomei F. Beyond the lesion: the epileptogenic
networks around cavernous angiomas. Epilepsy Res. 2014 May;108(4):701-8. doi:
10.1016/j.eplepsyres.2014.02.018. Epub 2014 Mar 12. PubMed PMID: 24661427.
Mosbah A, Tramoni E, Guedj E, Aubert S, Daquin G, Ceccaldi M, Félician O,
Bartolomei F. Clinical, neuropsychological, and metabolic characteristics of
transient epileptic amnesia syndrome. Epilepsia. 2014 May;55(5):699-706. doi:
10.1111/epi.12565. Epub 2014 Mar 1. PubMed PMID: 24580051.
Micoulaud-Franchi JA, Lanteaume L, Pallanca O, Vion-Dury J, Bartolomei F.
[Biofeedback and drug-resistant epilepsy: back to an earlier treatment?]. Rev
Neurol (Paris). 2014 Mar;170(3):187-96. doi: 10.1016/j.neurol.2013.10.011. Epub
2014 Feb 24. Review. French. PubMed PMID: 24576530.
McGonigal A, Bartolomei F. Parietal seizures mimicking psychogenic
nonepileptic seizures. Epilepsia. 2014 Jan;55(1):196-7. doi: 10.1111/epi.12465.
PubMed PMID: 24446959.
Bonini F, McGonigal A, Trébuchon A, Gavaret M, Bartolomei F, Giusiano B,
Chauvel P. Frontal lobe seizures: from clinical semiology to localization.
Epilepsia. 2014 Feb;55(2):264-77. doi: 10.1111/epi.12490. Epub 2013 Dec 24.
PubMed PMID: 24372328.
Hewett R, Bartolomei F. Epilepsy and the cortical vestibular system: tales of
dizziness and recent concepts. Front Integr Neurosci. 2013 Nov 11;7:73. doi:
10.3389/fnint.2013.00073. eCollection 2013. Review. PubMed PMID: 24273498; PubMed
Central PMCID: PMC3822407.
Malinowska U, Badier JM, Gavaret M, Bartolomei F, Chauvel P, Bénar CG.
Interictal networks in magnetoencephalography. Hum Brain Mapp. 2014
Jun;35(6):2789-805. doi: 10.1002/hbm.22367. Epub 2013 Sep 18. PubMed PMID:
24105895.
Bartolomei F, McGonigal A, Naccache L. Alteration of consciousness in focal
epilepsy: the global workspace alteration theory. Epilepsy Behav. 2014
Jan;30:17-23. doi: 10.1016/j.yebeh.2013.09.012. Epub 2013 Oct 6. Review. PubMed
PMID: 24103816.
Trebuchon A, Bartolomei F, McGonigal A, Laguitton V, Chauvel P. Reversible
antisocial behavior in ventromedial prefrontal lobe epilepsy. Epilepsy Behav.
2013 Nov;29(2):367-73. doi: 10.1016/j.yebeh.2013.08.007. Epub 2013 Sep 24. PubMed
PMID: 24074892.
Picard F, Scavarda D, Bartolomei F. Induction of a sense of bliss by
electrical stimulation of the anterior insula. Cortex. 2013
Nov-Dec;49(10):2935-7. doi: 10.1016/j.cortex.2013.08.013. Epub 2013 Sep 3. PubMed
PMID: 24074887.
Gavaret M, Badier JM, Bartolomei F, Bénar CG, Chauvel P. MEG and EEG
sensitivity in a case of medial occipital epilepsy. Brain Topogr. 2014
Jan;27(1):192-6. doi: 10.1007/s10548-013-0317-7. Epub 2013 Sep 5. PubMed PMID:
24005334.
Bartolomei F, Bettus G, Stam CJ, Guye M. Interictal network properties in
mesial temporal lobe epilepsy: a graph theoretical study from intracerebral
recordings. Clin Neurophysiol. 2013 Dec;124(12):2345-53. doi:
10.1016/j.clinph.2013.06.003. Epub 2013 Jun 28. PubMed PMID: 23810635.
Bonini F, McGonigal A, Wendling F, Régis J, Scavarda D, Carron R, Chauvel P,
Bartolomei F. Epileptogenic networks in seizures arising from motor systems.
Epilepsy Res. 2013 Sep;106(1-2):92-102. doi: 10.1016/j.eplepsyres.2013.04.011.
Epub 2013 May 30. PubMed PMID: 23726290.
Blümcke I, Thom M, Aronica E, Armstrong DD, Bartolomei F, Bernasconi A,
Bernasconi N, Bien CG, Cendes F, Coras R, Cross JH, Jacques TS, Kahane P, Mathern
GW, Miyata H, Moshé SL, Oz B, Özkara Ç, Perucca E, Sisodiya S, Wiebe S, Spreafico
R. International consensus classification of hippocampal sclerosis in temporal
lobe epilepsy: a Task Force report from the ILAE Commission on Diagnostic
Methods. Epilepsia. 2013 Jul;54(7):1315-29. doi: 10.1111/epi.12220. Epub 2013 May
20. PubMed PMID: 23692496.
Lambert I, Arthuis M, McGonigal A, Wendling F, Bartolomei F. Alteration of
global workspace during loss of consciousness: a study of parietal seizures.
Epilepsia. 2012 Dec;53(12):2104-10. doi: 10.1111/j.1528-1167.2012.03690.x. Epub
2012 Sep 27. PubMed PMID: 23016829.
Chauvière L, Doublet T, Ghestem A, Siyoucef SS, Wendling F, Huys R, Jirsa V,
Bartolomei F, Bernard C. Changes in interictal spike features precede the onset
of temporal lobe epilepsy. Ann Neurol. 2012 Jun;71(6):805-14. doi:
10.1002/ana.23549. PubMed PMID: 22718546.
Guedj E, McGonigal A, Vaugier L, Mundler O, Bartolomei F. Metabolic brain PET
pattern underlying hyperkinetic seizures. Epilepsy Res. 2012 Sep;101(3):237-45.
doi: 10.1016/j.eplepsyres.2012.04.008. Epub 2012 May 1. PubMed PMID: 22551665.
Lanteaume L, Guedj E, Bastien-Toniazzo M, Magalahaes A, Mundler O, Bartolomei
F. Cognitive and metabolic correlates of emotional vulnerability in patients with
temporal lobe epilepsy. J Neurol Neurosurg Psychiatry. 2012 May;83(5):522-8. doi:
10.1136/jnnp-2011-301219. Epub 2012 Jan 31. PubMed
