Radiopharmacie

Recherche :

• Centre européen en imagerie Medical (CERIMED)
• Imagerie préclinique
• Développement de nouveaux radiotraceurs diagnostics
• Optimisation de la radioprotection en médecine nucléaire

Publications :

• EarlyAnesthetic Preconditioning in Mixed Cortical Neuronal-Glial Cell Cultures Subjected to Oxygen-Glucose Deprivation: The Role of Adenosine Triphosphate Dependent Potassium Channels and Reactive Oxygen Species in Sevoflurane-Induced Neuroprotection. Lionel J. Velly, MD, Paula T. Canas, MD, Benjamin A. Guillet, PhD, Christelle N. Labrande, PhD, Frédérique M. Masmejean, André L. Nieoullon, PhD, François M. Gouin, MD, Nicolas J. Bruder,MD, and Pascale S. Pisano, PhD Anesth Analg. 2009 Mar;108(3):955-63

• Sevoflurane preconditioning against focal cerebral ischemia: Sustain inhibition of apoptosis in the face of transient improvement of neurological outcome. Jean-Laurent Codaccioni, Lionel J. Velly. Chahrazad Moubarik,, Nicolas J. Bruder,Benjamin A. Guillet and Pascale S. Pisano Anesthesiology, 2009 Jun;110(6):1271-8

• Chocolate intake associated with failed labeling of (99m)Tc red blood cells. Bustani H, Colavolpe C, Imbert-Joscht I, Havlik P, Pisano P, Guillet BA. J Nucl Med Technol. 2009 Jun;37(2):107-10.

• Soluble CD146 displays angiogenic properties and promotesneovascularisation in experimental hind limb ischemia. Harhouri K, Kebir A, Guillet B, Foucault-Bertaud A, Voytenko S, Piercecchi-Marti MD, Berenguer C, Lamy E, Vely F, Pisano P, Ouafik L, Sabatier F, Sampol J, Bardin N, Dignat-George F, Blot-Chabaud M. Blood. 2010, 2010 May 6;115(18):3843-51

• Transplanted late outgrowth endothelial cells inhibit apoptosis and improve angiogenesis and neurological outcome after strokeC. Moubarik, B. Guillet, M.D. Pierchecci, F. Sabatier, F. Dignat-George, P. Pisano Stem Cell Rev and Reports, published on line June 2010

• CD146 short isoform increases the pro-angiogenic potential of endothelial progenitor cells in vitro and in vivo Abdeldjalil Kebir, Karim Harhouri, Benjamin Guillet, Jia Wei Liu, Alexandrine Foucault-Bertaud, Edouard Lamy, Elise Kaspi, Frédéric Vely, Florence Sabatier, José Sampol, Pascale Pisano, Egbert K.O. Kruithof,  Nathalie Bardin, Françoise Dignat-George and Marcel Blot-Chabaud Circul. Res 2010 Jul 9;107(1):66-75.

• Population pharmacokinetics analysis of mycophenolic acid in adult kidney transplant patients with chronic graft dysfunction. Guillet BA, Simon NS, Purgus R, Botta C, Morange S, Berland Y, Pisano PS. Ther Drug Monit. 2010 Aug;32(4):427-32

• Erythropoietin and cerebral protection after acute injuries: a double-edged sword? L. Velly, L. Pellegrini, B. Guillet, N. Bruder, P. Pisano. Pharmacologyand Therapeutics, 2010 Dec;128(3):445-59.

• Interests in Angiogenesis Inhibitor Drugs Approved for the Treatment of Cancers. Bennis Y, Guillet B, Curti C, et al. THERAPIE  2010,  Volume: 65   Issue: 2   Pages: 95-105  

• Ex vivopriming of late outgrowth endothelial progenitor cells with erythropoietin before transplantation enhances their angiogenic potential and requires the CD131 receptor subunit.  Bennis Youssef PhD, Sarlon Gabrielle MD, Guillet Benjamin, Blot- Chabot Marcel, Dignat-George Françoise, Sabatier Florence, and Pisano Pascale. Submitted