Pédiatrie

Recherches

• Noyade
• Traumatisés sévères
• Arrêt cardiaque
• Syndrome coronarien aigu

Publications remarquables de ces 10 dernières années

• Early point-of-care echocardiography as a predictive factor for absence of return of spontaneous circulatory in out-of-hospital cardiac arrests: A multicentre observational study
  Javaudin F, Papin M, Le Bastard Q, Thibault M, Boishardy T, Brau F, Laribi S, Petrovic T, Peluchon T, Markarian T, Volteau C, Arnaudet I, Pes P, Le Conte P.
  Resuscitation. 2024 Aug 21;203:110373.
• Resuscitation and Forensic Factors Influencing Outcome in Penetrating Cardiac Injury
  Aumaitre A, Delteil C, Tuchtan L, Piercecchi-Marti MD, Gainnier M, Carvelli J, Boussen S, Bruder N, Heireche F, Florant T, Gaillat F, Lagier D, Porto A, Velly L, Simeone P.
  Diagnostics (Basel). 2024 Jul 1;14(13):1406.
• Development and validation of a clinico-biological score to predict outcomes in patients with drowning-associated cardiac arrest
  Reizine F, Michelet P, Delbove A, Rieul G, Bodenes L, Bouju P, Fillâtre P, Frérou A, Lesieur O, Markarian T, Gacouin A; DrownAP study group.
  Am J Emerg Med. 2024 Jul;81:69-74.
• The association between regional guidelines compliance and mortality in severe trauma patients: an observational, retrospective study
  Duclos G, Heireche F, Siroutot M, Delamarre L, Sartorius MA, Mergueditchian C, Velly L, Carvelli J, Bordais A, Pilarczyk E, Leone M.
  Eur J Emerg Med. 2024 Jun 1;31(3):208-215.
• Drowning Classification: A Reappraisal of Clinical Presentation and Prognosis for Severe Cases
  Markarian T, Loundou A, Heyer V, Marimoutou C, Borghese L, Coulange M, Michelet P.
  Chest. 2020 Aug;158(2):596-602.
• Out-of-hospital Times Using Helicopters Versus Ground Services for Emergency Patients
  Stowell A, Bobbia X, Cheret J, Genre Grandpierre R, Moreau A, Pommet S, Lefrant JY, de La Coussaye JE, Markarian T, Claret PG.
  Air Med J. 2019 Mar-Apr;38(2):100-105.
• Evaluation and Comparison of Different Prehospital Triage Scores of Trauma Patients on In-Hospital Mortality
  Cassignol A, Markarian T, Cotte J, Marmin J, Nguyen C, Cardinale M, Pauly V, Kerbaul F, Meaudre E, Bobbia X.
  Prehosp Emerg Care. 2019 Jul-Aug;23(4):543-550.
• Drowning in fresh or salt water: respective influence on respiratory function in a matched cohort study
  Michelet P, Dusart M, Boiron L, Marmin J, Mokni T, Loundou A, Coulange M, Markarian T.
  Eur J Emerg Med. 2019 Oct;26(5):340-344.
• Unmanned aerial vehicles (drones) to prevent drowning
  Seguin C, Blaquière G, Loundou A, Michelet P, Markarian T.
  Resuscitation. 2018 Jun;127:63-67.
• Early management of severe pelvic injury (first 24 hours)
  Incagnoli P, Puidupin A, Ausset S, Beregi JP, Bessereau J, Bobbia X, Brun J, Brunel E, Buléon C, Choukroun J, Combes X, David JS, Desfemmes FR, Garrigue D, Hanouz JL, Plénier I, Rongieras F, Vivien B, Gauss T, Harrois A, Bouzat P, Kipnis E.
  Anaesth Crit Care Pain Med. 2019 Apr;38(2):199-207.
• Epidemiology of unintentional drowning in a metropolis of the French Mediterranean coast: a retrospective analysis (2000-2011)
  Bessereau J, Fournier N, Mokhtari T, Brun PM, Desplantes A, Grassineau D, Guilhem N, Heireche F, Kerbaul F, Mancini J, Meyran D, Toesca R, Topin F, Tsapis M, Auffray JP, Michelet P.
  Int J Inj Contr Saf Promot. 2016 Sep;23(3):317-22.
• COMparison of Platelet reactivity following prAsugrel and ticagrelor loading dose in ST-Segment elevation myocardial infarctION patients: The COMPASSION study
  Laine M, Gaubert M, Frère C, Peyrol M, Thuny F, Yvorra S, Chelini V, Bultez B, Luigi S, Mokrani Z, Bessereau J, Toesca R, Champenois A, Dignat-George F, Paganelli F, Bonello L.
  Platelets. 2015;26(6):570-2.
• 2-point ultrasonography to confirm correct position of the gastric tube in prehospital setting
  Brun PM, Chenaitia H, Lablanche C, Pradel AL, Deniel C, Bessereau J, Melaine R. Mil Med. 2014 Sep;179(9):959-63.
• Effect of ticagrelor-related dyspnea on compliance with therapy in acute coronary syndrome patients
  Gaubert M, Laine M, Richard T, Fournier N, Gramond C, Bessereau J, Mokrani Z, Bultez B, Chelini V, Barnay P, Maillard L, Paganelli F, Bonello L.
  Int J Cardiol. 2014 Apr 15;173(1):120-1.
• Prehospital ultrasound thoracic examination to improve decision making, triage, and care in blunt trauma
  Brun PM, Bessereau J, Levy D, Billeres X, Fournier N, Kerbaul F.
  Am J Emerg Med. 2014 Jul;32(7):817.e1-2.
• Stay and play eFAST or scoop and run eFAST? That is the question!
  Brun PM, Bessereau J, Chenaitia H, Pradel AL, Deniel C, Garbaye G, Melaine R, Bylicki O, Lablanche C.
  Am J Emerg Med. 2014 Feb;32(2):166-70.
• Ticagrelor versus prasugrel in diabetic patients with an acute coronary syndrome. A pharmacodynamic randomised study
  Laine M, Frère C, Toesca R, Berbis J, Barnay P, Pansieri M, Michelet P, Bessereau J, Camilleri E, Ronsin O, Helal O, Paganelli F, Dignat-George F, Bonello L.
  Thromb Haemost. 2014 Feb;111(2):273-8.

Participation à des études multicentriques

• CPAP Drowning
  Porteur de projet : Pierre MICHELET (Marseille)
  Objectif : évaluation de la ventilation non invasive chez le patient noyé en détresse respiratoire aiguë
• CELEBRATE
  Porteur de projet : Gilles MONTALESCOT (Paris)
  Objectif : évaluation de la sécurité et l’efficacité d’une injection sous-cutanée de zalunfiban en préhospitalier chez des patients présentant un SCA ST+
• IPSTRAUC
  Porteur de projet : François SAGET (Rennes)
  Objectif : impact sur les parcours de soins d’une nouvelle prise en charge des traumatisés cervicaux chez les patients conscients stables en préhospitalier
• TRAUMATRIX
  Porteur de projet : Tobias GAUSS (Grenoble)
  Objectif : utilisation de modèles d’intelligence artificielle en régulation pour quantifier les besoins du patient traumatisé sévère et ainsi réduire les risques associés au sous / sur triage

Les axes du service sont le sepsis, les détresses respiratoires et hémodynamiques, les traumatismes et inflammations, la médecine péri-opératoire.

Les publications réalisées au sein du service :

• Bège T, Pauly V, Orleans V, Boyer L, Leone M. Epidemiology of trauma in France: mortality and risk factors based on a national medico-administrative database. Anaesth Crit Care Pain Med. 2019 Feb 23
• Vitte J, Amadei L, Gouitaa M, Mezouar S, Zieleskiewicz L, Albanese J, Bruder N, Lagier D, Mertès PM, Mège JL, Schwartz LB, Leone M. Paired acute-baseline serum tryptase levels in perioperative anaphylaxis: An observational study. Allergy. 2019 Jun;74(6):1157-1165
• Duclos G, Cantaloube M, Medam S, Resseguier N, Leone M. Preliminary results of synergy between norepinephrine and terlipressin during septic shock. Intensive Care Med. 2019 May;45(5):730-732
• Mathieu C, Pastene B, Cassir N, Martin-Loeches I, Leone M. Efficacy and safety of antimicrobial de-escalation as a clinical strategy. Expert Rev Anti Infect Ther. 2019 Feb;17(2):79-88
• Duclos G, Resseguier N, Ronfle R, Thomas PA, Leone M. Complemental analysis about postoperative opioid consumption between video-assisted thoracic surgery(VATS) and robotic-assisted thoracic surgery (RATS) for early-stage lung cancer. J Thorac Dis. 2018 Oct;10(10):E764-E765
• Duclos G, Hili A, Resseguier N, Kelway C, Haddam M, Bourgoin A, Carcopino X, Zieleskiewicz L, Leone M. Clearsight™ use for haemodynamic monitoring during the third trimester of pregnancy - a validation study. Int J Obstet Anesth. 2018
• Coiffard B, Diallo AB, Culver A, Mezouar S, Hammad E, Vigne C, Nicolino-Brunet C, Dignat-George F, Baumstarck K, Boucekine M, Leone M, Mege JL. Circadian Rhythm Disruption and Sepsis in Severe Trauma Patients. Shock. 2019 Jul;52(1):29-36
• Duclos G, Charvet A, Resseguier N, Trousse D, D'Journo XB, Zieleskiewicz L, Thomas PA, Leone M. Postoperative morphine consumption and anaesthetic management of patients undergoing video-assisted or robotic-assisted lung resection: a prospective, propensity score-matched study. J Thorac Dis. 2018 Jun;10(6):3558-3567
• Zieleskiewicz L, Fresco R, Duclos G, Antonini F, Mathieu C, Medam S, Vigne C, Poirier M, Roche PH, Bouzat P, Kerbaul F, Scemama U, Bège T, Thomas PA, Flecher X, Hammad E, Leone M. Integrating extended focused assessment with sonography for trauma (eFAST) in the initial assessment of severe trauma: Impact on the management of 756 patients. Injury. 2018 Oct;49(10):1774-1780
• Zieleskiewicz L, Bouvet L, Einav S, Duclos G, Leone M. Diagnostic point-of-care ultrasound: applications in obstetric anaesthetic management. Anaesthesia. 2018 Oct;73(10):1265-1279
• Medam S, Zieleskiewicz L, Duclos G, Baumstarck K, Loundou A, Alingrin J, Hammad E, Vigne C, Antonini F, Leone M. Risk factors for death in septic shock: A retrospective cohort study comparing trauma and non-trauma patients. Medicine(Baltimore). 2017 Dec;96(50):e9241
• Zieleskiewicz L, Noel A, Duclos G, Haddam M, Delmas A, Bechis C, Loundou A, Blanc J, Mignon A, Bouvet L, Einav S, Bourgoin A, Leone M. Can point-of-care ultrasound predict spinal hypotension during caesarean section? A prospective observational study. Anaesthesia. 2018 Jan;73(1):15-22
• Futier E, Lefrant JY, Guinot PG, Godet T, Lorne E, Cuvillon P, Bertran S, Leone M, Pastene B, Piriou V, Molliex S, Albanese J, Julia JM, Tavernier B, Imhoff E, Bazin JE, Constantin JM, Pereira B, Jaber S; INPRESS Study Group. Effect of Individualized vs Standard Blood Pressure Management Strategies on Postoperative Organ Dysfunction Among High-Risk Patients Undergoing Major Surgery: A Randomized Clinical Trial. JAMA. 2017 Oct 10;318(14):1346-1357
• Duclos G, Zieleskiewicz L, Antonini F, Mokart D, Paone V, Po MH, Vigne C, Hammad E, Potié F, Martin C, Medam S, Leone M. Implementation of an electronic checklist in the ICU: Association with improved outcomes. Anaesth Crit Care Pain Med. 2018 Feb;37(1):25-33